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NumPy

NumPy developers (NumFOCUS) · DataFrames & array computing

Foundational Python library for n-dimensional arrays, vectorized math, linear algebra, random numbers and the array API used by the scientific stack

BSD-3-ClauseOpen sourceFreeLocalBroken

Odoo

Odoo S.A. · CRM & business operations

Modular open-source business suite (CRM, invoicing, accounting, inventory, website, HR) with an LGPL community edition and a hosted or licensed enterprise edition

LGPL-3.0-onlyOpen sourceFreemiumSelf-hostedBroken

OpenAI Agents SDK

OpenAI · Agent frameworks & orchestration

Lightweight open-source Python and TypeScript framework for agents, handoffs, guardrails, sessions and tracing, defaulting to OpenAI's Responses API with adapters for other providers

MITOpen sourceFreeLocalSelf-hostedNov 2, 2026

pandas

pandas development team (NumFOCUS) · DataFrames & array computing

In-depth entry

The standard Python DataFrame library for labeled tabular data, time series and I/O to CSV, Excel, SQL, Parquet and more

BSD-3-ClauseOpen sourceFreeLocalNov 2, 2026

Pandera

Union.ai (Pandera project, created by Niels Bantilan) · Data quality & validation

Lightweight Python library for declaring and validating DataFrame schemas for pandas, Polars, PySpark and other backends, with type-hint style models

MITOpen sourceFreeLocalNov 2, 2026

Playwright

Microsoft · Testing & QA

In-depth entry

Microsoft's browser automation and end-to-end testing framework driving Chromium, Firefox and WebKit from one API in TypeScript, Python, Java and .NET

Apache-2.0Open sourceFreeLocalSelf-hostedNov 2, 2026

Plotly

Plotly Technologies Inc. · Data visualization

MIT-licensed interactive charting libraries for Python (plotly.py), JavaScript (plotly.js) and R, plus the Dash framework for analytical web apps

MITOpen sourceFreeLocalNov 2, 2026

Polars

Polars (Ritchie Vink and contributors) · DataFrames & array computing

In-depth entry

Rust-based DataFrame library with Python, Rust, Node and R bindings offering lazy query optimization, multithreading and Arrow-native memory

MITOpen sourceFreeLocalNov 2, 2026

Positron

Posit Software, PBC · Mathematical & statistical computing

Posit's multi-language data-science IDE built on Code OSS, with first-class R and Python consoles, variables and plots panes, under the Elastic License 2.0

Elastic-2.0FreeLocalNov 2, 2026

Prefect

Prefect Technologies, Inc. · ETL/ELT & orchestration

Python workflow orchestration library and server where decorated functions become observable, retryable flows, with Prefect Cloud as hosted option

Apache-2.0Open sourceFreemiumLocalSelf-hostedRedirected

Project Jupyter

Project Jupyter (NumFOCUS) · Notebooks & interactive computing

In-depth entry

Open-source computational notebook ecosystem: the .ipynb format, kernels for Python, R and Julia, JupyterLab and Notebook interfaces and JupyterHub

BSD-3-ClauseOpen sourceFreeLocalSelf-hostedNov 2, 2026

Pydantic

Pydantic Services Inc. · Data quality & validation

Python data-validation library using type hints to parse, validate and serialize models, with a Rust core; the schema layer behind FastAPI and many LLM SDKs

MITOpen sourceFreeLocalBroken

Pydantic AI

Pydantic Services Inc. · Agent frameworks & orchestration

Type-safe Python agent framework from the Pydantic team with validated structured outputs, dependency injection, swappable model providers, MCP, durable execution and evals

MITOpen sourceFreeLocalSelf-hostedNov 2, 2026

PyPortfolioOpt

Robert Andrew Martin and contributors · Portfolio & wealth management

Python library for portfolio optimization: efficient frontier, Black-Litterman, hierarchical risk parity and discrete allocation

MITOpen sourceFreeLocalNov 2, 2026

pytest

pytest-dev team · Testing & QA

Python testing framework with plain assert statements, fixtures, parametrization and a large plugin ecosystem, the de facto standard for Python test suites

MITOpen sourceFreeLocalNov 2, 2026

Python

Python Software Foundation · Programming languages & runtimes

In-depth entry

General-purpose, dynamically typed programming language with a large standard library and the dominant ecosystem for data science and machine learning

PSF-2.0Open sourceFreeLocalSelf-hostedBroken

PyTorch

PyTorch Foundation (Linux Foundation) · Training & fine-tuning

Open-source deep-learning framework with eager tensors, autograd, torch.compile and distributed training, governed by the PyTorch Foundation and the base of most LLM tooling

BSD-3-ClauseOpen sourceFreeLocalSelf-hostedBroken

QGIS

QGIS.org association · GIS & mapping

In-depth entry

Open-source desktop GIS for viewing, editing, analysing and publishing vector and raster geodata, extensible with Python plugins

GPL-2.0-or-laterOpen sourceFreeLocalBroken

QuantConnect

QuantConnect Corporation · Financial analysis & investing

In-depth entry

Algorithmic trading platform built on the open-source LEAN engine, with cloud backtesting, research notebooks and brokerage-connected live trading

Apache-2.0FreemiumPaidLocalNov 2, 2026

QuantLib

QuantLib project (Luigi Ballabio and contributors) · Financial analysis & investing

In-depth entry

Open-source C++ library for quantitative finance covering instruments, term structures, pricing engines and calendars, with Python and other bindings

BSD-3-ClauseOpen sourceFreeLocalNov 2, 2026

Quarto

Posit Software, PBC · Academic writing & publishing

In-depth entry

Open-source scientific publishing system from Posit that renders Markdown with executable Python, R, Julia or Observable code to HTML, PDF, Word, slides, websites and books via Pandoc

MITFreeOpen sourceLocalNov 2, 2026

Ragas

Vibrant Labs (formerly Exploding Gradients) · Prompting, evaluation & observability

Open-source Python library for evaluating LLM and RAG applications with LLM-driven and custom metrics, experiments, dataset management and result tracking

Apache-2.0Open sourceFreeLocalBroken

Ray

Ray project (Anyscale and contributors) · Distributed & parallel computing

In-depth entry

Open-source Python framework for distributing tasks, actors and ML workloads across a cluster, with libraries for data processing, training, tuning, serving and reinforcement learning

Apache-2.0Open sourceFreeLocalSelf-hostedBroken

Riskfolio-Lib

Dany Cajas · Portfolio & wealth management

Python library for quantitative portfolio optimization with many risk measures, robust estimators and hierarchical clustering models

BSD-3-ClauseOpen sourceFreeLocalNov 2, 2026

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