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EconML

PyWhy (originally Microsoft Research) · Econometrics & causal inference

Python library for heterogeneous treatment-effect estimation with machine learning: double ML, doubly robust learners, causal forests, meta-learners, IV and policy learning

MITFreeOpen sourceLocalNov 2, 2026

edgartools

Dwight Gunning · SEC/EDGAR & corporate filings

MIT-licensed Python library for SEC EDGAR: company and filing objects, XBRL financial statements, Form 3/4/5, 13F and proxy parsing into pandas, with the SEC identity requirement built in

MITFreeOpen sourceLocalNov 2, 2026

ElevenLabs

ElevenLabs, Inc. · Voice, vision & multimodal AI

Hosted voice AI platform: text-to-speech and speech-to-text models, voice cloning, dubbing, music and sound effects, a voice-agent builder and a REST API with Python and TypeScript SDKs

ProprietaryFreemiumPaidNov 2, 2026

Exa

Exa Labs · Search & web-data APIs

Search API for AI agents built on Exa's own web index, offering search, page contents, deep research and asynchronous agent endpoints with Python and JavaScript SDKs

ProprietaryFreemiumUsage-basedNov 2, 2026

exo

Exo Labs · Distributed & parallel computing

Open-source software that pools several Apple Silicon Macs (and Linux hosts) into one local inference cluster, sharding large models across devices with MLX

Apache-2.0Open sourceFreeLocalSelf-hostedNov 2, 2026

Fail2Ban

Fail2Ban project · Security tools

Log-scanning intrusion-prevention daemon that temporarily bans IP addresses showing repeated authentication failures by updating firewall rules

GPL-2.0-or-laterOpen sourceFreeSelf-hostedNov 2, 2026

Gemini API

Google (Chrome DevTools team) · Model providers & APIs

Google's developer API for the Gemini model family, keyed from Google AI Studio, with function calling, Search grounding, Live API, image and video generation and a free tier

ProprietaryFreemiumUsage-basedNov 2, 2026

Great Expectations (GX Core)

Great Expectations project (open-source stewardship by Fivetran) · Data quality & validation

Python data-quality framework that declares Expectations about datasets, validates them against pandas, Spark or SQL sources and produces Data Docs

Apache-2.0Open sourceFreeLocalSelf-hostedNov 2, 2026

GroqCloud

Groq, Inc. · Model providers & APIs

Low-latency hosted inference API for open-weight models on Groq's LPU hardware, OpenAI-compatible, with speech-to-text, text-to-speech, tool use and batch tiers

ProprietaryUsage-basedEnterpriseNov 2, 2026

H3

Uber Technologies (open-source project) · GIS & mapping

Hexagonal hierarchical geospatial indexing system from Uber with a C core and bindings for Python, JavaScript, Java and SQL engines

Apache-2.0Open sourceFreeLocalNov 2, 2026

Instructor

Jason Liu and contributors (567 Labs) · Agent frameworks & orchestration

Python library for extracting validated structured data from LLM responses using Pydantic models, with automatic retries, streaming partials and support for many providers

MITOpen sourceFreeLocalNov 2, 2026

JAX

Google (Chrome DevTools team) · Training & fine-tuning

Python library for NumPy-style array computing with composable transformations (jit, grad, vmap, shard_map) compiled through XLA to CPU, GPU and TPU

Apache-2.0Open sourceFreeLocalSelf-hostedNov 2, 2026

LangChain

LangChain, Inc. · Agent frameworks & orchestration

Open-source Python and JavaScript framework whose create_agent harness builds tool-using agents on the LangGraph runtime with swappable model providers and middleware

MITOpen sourceFreeLocalSelf-hostedNov 2, 2026

linearmodels

Kevin Sheppard · Econometrics & causal inference

Python package by Kevin Sheppard adding panel data, instrumental-variable, system (SUR/3SLS) and asset-pricing estimators missing from statsmodels

NCSAFreeOpen sourceLocalNov 2, 2026

LlamaIndex

LlamaIndex, Inc. · Agent frameworks & orchestration

Open-source Python framework for retrieval-augmented agents over your data, with connectors, indexes, query engines and event-driven workflows, alongside the commercial LlamaParse document platform

MITOpen sourceFreeLocalSelf-hostedNov 2, 2026

marimo

marimo (acquisition by CoreWeave announced October 2025) · Notebooks & interactive computing

Reactive Python notebook stored as a plain .py file that re-runs dependent cells automatically and doubles as a script or web app

Apache-2.0Open sourceFreeLocalSelf-hostedNov 2, 2026

Matplotlib

Matplotlib Development Team (NumFOCUS) · Data visualization

The foundational Python plotting library for static, publication-quality figures with full control over every element, exported to PDF, SVG, PNG and PGF

Open sourceOpen sourceFreeLocalNov 2, 2026

Mistral AI

Mistral AI · Model providers & APIs

French model provider offering open-weight and proprietary models through the Studio API, OCR and speech models, the Vibe agent for productivity and coding, and self-deployment options

MixedFreemiumUsage-basedSelf-hostedBroken

MkDocs

MkDocs project (Tom Christie and contributors) · Documentation tooling

Python static site generator for project documentation that builds a navigable site from Markdown files and a single YAML configuration

BSD-2-ClauseOpen sourceFreeLocalNov 2, 2026

MLX Whisper

Apple Inc. · Apple Silicon ML & MLX

Port of OpenAI's Whisper speech-recognition models to MLX, offering a CLI and Python API for local transcription on Apple Silicon

MITOpen sourceFreeLocalNov 2, 2026

NumPy

NumPy developers (NumFOCUS) · DataFrames & array computing

Foundational Python library for n-dimensional arrays, vectorized math, linear algebra, random numbers and the array API used by the scientific stack

BSD-3-ClauseOpen sourceFreeLocalBroken

Odoo

Odoo S.A. · CRM & business operations

Modular open-source business suite (CRM, invoicing, accounting, inventory, website, HR) with an LGPL community edition and a hosted or licensed enterprise edition

LGPL-3.0-onlyOpen sourceFreemiumSelf-hostedBroken

OpenAI Agents SDK

OpenAI · Agent frameworks & orchestration

Lightweight open-source Python and TypeScript framework for agents, handoffs, guardrails, sessions and tracing, defaulting to OpenAI's Responses API with adapters for other providers

MITOpen sourceFreeLocalSelf-hostedNov 2, 2026

OpenRouter

OpenRouter, Inc. · Model providers & APIs

Unified API gateway to hundreds of models from many providers with automatic fallbacks, credit-based pass-through billing, BYOK, free models and data-policy routing

ProprietaryFreemiumUsage-basedBroken

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