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ComfyUI

Comfy Org · Voice, vision & multimodal AI

Open-source node-based interface and inference engine for diffusion and other generative models (image, video, audio, 3D), runnable locally with desktop apps or as a hosted cloud

GPL-3.0-onlyOpen sourceFreeLocalNov 2, 2026

exo

Exo Labs · Distributed & parallel computing

Open-source software that pools several Apple Silicon Macs (and Linux hosts) into one local inference cluster, sharding large models across devices with MLX

Apache-2.0Open sourceFreeLocalSelf-hostedNov 2, 2026

Positron

Posit Software, PBC · Mathematical & statistical computing

Posit's multi-language data-science IDE built on Code OSS, with first-class R and Python consoles, variables and plots panes, under the Elastic License 2.0

Elastic-2.0FreeLocalNov 2, 2026

QGIS

QGIS.org association · GIS & mapping

In-depth entry

Open-source desktop GIS for viewing, editing, analysing and publishing vector and raster geodata, extensible with Python plugins

GPL-2.0-or-laterOpen sourceFreeLocalBroken

Unsloth

Unsloth AI · Training & fine-tuning

Open-source framework for fine-tuning and running LLMs with reduced memory, covering LoRA, QLoRA, full fine-tuning and RL, GGUF export, Dynamic quantizations and a local Studio/Desktop UI

Apache-2.0Open sourceFreeLocalSelf-hostedNov 2, 2026

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