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AutoGen

Microsoft · Agent frameworks & orchestration

Microsoft's multi-agent framework (Core, AgentChat, Extensions, Studio) for Python and .NET, now archived with users directed to Microsoft Agent Framework

MITOpen sourceFreeLocalSelf-hostedDeprecatedNov 2, 2026

CrewAI

CrewAI, Inc. · Agent frameworks & orchestration

Open-source Python framework for role-based multi-agent crews and event-driven flows, with a commercial enterprise console for deploying, monitoring and triggering automations

MITOpen sourceFreemiumLocalSelf-hostedNov 2, 2026

LangChain

LangChain, Inc. · Agent frameworks & orchestration

Open-source Python and JavaScript framework whose create_agent harness builds tool-using agents on the LangGraph runtime with swappable model providers and middleware

MITOpen sourceFreeLocalSelf-hostedNov 2, 2026

LlamaIndex

LlamaIndex, Inc. · Agent frameworks & orchestration

Open-source Python framework for retrieval-augmented agents over your data, with connectors, indexes, query engines and event-driven workflows, alongside the commercial LlamaParse document platform

MITOpen sourceFreeLocalSelf-hostedNov 2, 2026

OpenAI Agents SDK

OpenAI · Agent frameworks & orchestration

Lightweight open-source Python and TypeScript framework for agents, handoffs, guardrails, sessions and tracing, defaulting to OpenAI's Responses API with adapters for other providers

MITOpen sourceFreeLocalSelf-hostedNov 2, 2026

Pydantic

Pydantic Services Inc. · Data quality & validation

Python data-validation library using type hints to parse, validate and serialize models, with a Rust core; the schema layer behind FastAPI and many LLM SDKs

MITOpen sourceFreeLocalBroken

Pydantic AI

Pydantic Services Inc. · Agent frameworks & orchestration

Type-safe Python agent framework from the Pydantic team with validated structured outputs, dependency injection, swappable model providers, MCP, durable execution and evals

MITOpen sourceFreeLocalSelf-hostedNov 2, 2026

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