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AutoGen

Microsoft · Agent frameworks & orchestration

Microsoft's multi-agent framework (Core, AgentChat, Extensions, Studio) for Python and .NET, now archived with users directed to Microsoft Agent Framework

MITOpen sourceFreeLocalSelf-hostedDeprecatedNov 2, 2026

ComfyUI

Comfy Org · Voice, vision & multimodal AI

Open-source node-based interface and inference engine for diffusion and other generative models (image, video, audio, 3D), runnable locally with desktop apps or as a hosted cloud

GPL-3.0-onlyOpen sourceFreeLocalNov 2, 2026

exo

Exo Labs · Distributed & parallel computing

Open-source software that pools several Apple Silicon Macs (and Linux hosts) into one local inference cluster, sharding large models across devices with MLX

Apache-2.0Open sourceFreeLocalSelf-hostedNov 2, 2026

LiteLLM

BerriAI · Prompting, evaluation & observability

In-depth entry

Open-source Python SDK and self-hosted AI gateway that calls 100+ LLM providers in the OpenAI format, with routing, fallbacks, virtual keys, budgets, spend tracking and logging callbacks

MITOpen sourceFreeLocalSelf-hostedNov 2, 2026

promptfoo

Promptfoo, Inc. · Prompting, evaluation & observability

Open-source, local-first CLI and library for evaluating prompts, models, RAG pipelines and agents, with automated red teaming and CI integration

MITOpen sourceFreeLocalSelf-hostedBroken

Ray

Ray project (Anyscale and contributors) · Distributed & parallel computing

In-depth entry

Open-source Python framework for distributing tasks, actors and ML workloads across a cluster, with libraries for data processing, training, tuning, serving and reinforcement learning

Apache-2.0Open sourceFreeLocalSelf-hostedBroken

Unsloth

Unsloth AI · Training & fine-tuning

Open-source framework for fine-tuning and running LLMs with reduced memory, covering LoRA, QLoRA, full fine-tuning and RL, GGUF export, Dynamic quantizations and a local Studio/Desktop UI

Apache-2.0Open sourceFreeLocalSelf-hostedNov 2, 2026

Visual Studio Code

Microsoft · IDEs & editors

In-depth entry

Free, extensible code editor from Microsoft with a large extension marketplace, integrated terminal, debugging, remote development and built-in AI assistance

MITFreeLocalNov 2, 2026

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