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AutoGen

Microsoft · Agent frameworks & orchestration

Microsoft's multi-agent framework (Core, AgentChat, Extensions, Studio) for Python and .NET, now archived with users directed to Microsoft Agent Framework

MITOpen sourceFreeLocalSelf-hostedDeprecatedNov 2, 2026

CrewAI

CrewAI, Inc. · Agent frameworks & orchestration

Open-source Python framework for role-based multi-agent crews and event-driven flows, with a commercial enterprise console for deploying, monitoring and triggering automations

MITOpen sourceFreemiumLocalSelf-hostedNov 2, 2026

DSPy

Stanford NLP and the DSPy community · Prompting, evaluation & observability

Python framework for programming language-model pipelines with typed signatures and modules, then optimizing prompts and weights automatically against a metric

MITOpen sourceFreeLocalSelf-hostedNov 2, 2026

LangChain

LangChain, Inc. · Agent frameworks & orchestration

Open-source Python and JavaScript framework whose create_agent harness builds tool-using agents on the LangGraph runtime with swappable model providers and middleware

MITOpen sourceFreeLocalSelf-hostedNov 2, 2026

LangGraph

LangChain, Inc. · Agent frameworks & orchestration

In-depth entry

Low-level orchestration framework and runtime for stateful, long-running agents expressed as graphs, with durable execution, checkpointing, human-in-the-loop and streaming

MITOpen sourceFreeLocalSelf-hostedNov 2, 2026

LlamaIndex

LlamaIndex, Inc. · Agent frameworks & orchestration

Open-source Python framework for retrieval-augmented agents over your data, with connectors, indexes, query engines and event-driven workflows, alongside the commercial LlamaParse document platform

MITOpen sourceFreeLocalSelf-hostedNov 2, 2026

OpenAI Agents SDK

OpenAI · Agent frameworks & orchestration

Lightweight open-source Python and TypeScript framework for agents, handoffs, guardrails, sessions and tracing, defaulting to OpenAI's Responses API with adapters for other providers

MITOpen sourceFreeLocalSelf-hostedNov 2, 2026

Pydantic AI

Pydantic Services Inc. · Agent frameworks & orchestration

Type-safe Python agent framework from the Pydantic team with validated structured outputs, dependency injection, swappable model providers, MCP, durable execution and evals

MITOpen sourceFreeLocalSelf-hostedNov 2, 2026

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